CT-based validation of the ESI – test for the assessment of emphysema by spirometry
The advanced clinical experimentation of the ESI theory was performed using dedicated math software in cooperation with the University of Florence, Italy, on a dataset of two hundred consecutive COPD patients who underwent High Resolution Computed Tomography CT scan and spirometry.
The study showed that CT metrics reflecting the severity of emphysema correlated more strongly with ESI (Emphysema Severity Index) than FEV1 and FEV1/FVC. Furthermore ESI was more independent from functional non- emphysematous gas trapping than standard obstruction indexes.
For validation details and info please read the following paper (Respiratory Research, 2019):
Spirometric assessment of emphysema presence and severity as measured by quantitative CT and CT-based radiomics in COPD
The current version of the ESI-test calculator is based on a novel real-time implementation of the theoretical ESI algorithm. This software was especially designed for clinical practice, pharmacologic trials, medical education and for the evaluation of emphysema whenever spirometry is the only available examination (the application results are still under validation, at the moment is intended for research use only).
The required input data are flow-volume measurements usually available in output reports provided by standard spirometers. (i.e. flow values, FVC). DLco% is not required for this analysis.
Recently, the performances achieved by the current real-time ESI test software have been studied on a large international database of smokers, ex smokers, COPD patients and the results obtained during the experimentation are very interesting. The analysis reports will be published on important international journals in the next months.